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KMID : 0859320100280020057
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Journal of the Korean Society for Therapeutic Radiology and Oncology
2010 Volume.28 No. 2 p.57 ~ p.63
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Immunohistochemical Study to Evaluate the Prognostic Significance of Four Biomolecular Markers in Radiotherapy of Nasopharyngeal Carcinoma
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Kim Yeon-Joo
Lee Seung-Hee
Wu Hong-Gyun
Ko Heoun-Jeong
Jeon Yoon-Kyung
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Abstract
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Purpose:We performed an immunohistochemical study with pre-treatment biopsy specimens to evaluate the prognostic significance of four biomolecular markers which can be used as a predictive assay for radiotherapy (RT) treatment of nasopharyngeal carcinoma (NPC).
Methods:From January 1998 through December 2006, 68 patients were histologically diagnosed as non-metastatic NPC and treated by RT. Only 38 patients had the paraffin block for the immunohistochemical study. Thirty-one patients had undifferentiated carcinoma and 7 patients had squamous cell carcinoma. Thirty- two patients (84%) had advanced stage NPC (2002 AJCC Stage III∼IV). Immunohistochemical staining was performed for Met, COX-2, nm23-H1, and epidermal growth factor receptor (EGFR) expression using routine methods.
Results:The median follow-up time was 30 months (range, 11 to 83 months) for all patients, and 39 months (range, 19 to 83 months) for surviving patients. The 5-year overall survival (OS) rate of the patients with high Met extent (≥50%) was significantly lower than that of the patients with low Met extent (48% vs. 84%, p=0.02). In addition, Met extent was also a significant prognostic factor in multivariate analysis (p=0.01). No correlation was observed between Met extent and T stage, N stage, stage group, gender, age, and the response to chemotherapy or RT. Met extent showed moderate correlation with COX-2 expression (Pearson coefficient 0.496, p＜0.01), but COX-2 expression did not affect OS. Neither nm23-H1 or EGFR expression was a prognostic factor for OS in this study.
Conclusions:High Met extent (≥50%) might be an independent prognostic factor that predicts poor OS in NPC treated with RT.
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KEYWORD
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Nasopharyngeal carcinoma, Radiotherapy, Prognostic factor, Immunohistochemical staining, Met
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